FAME Lab [(F)unctional (A)rchitecture of (M)ammals in their (E)nvironment], is a research group of 15 researchers investigating the health and performance effects of environmental factors with a particular focus on the effects of heat. In recent years, our work is primarily focused on climate change impacts on human health, including on the effects of climate change on health and productivity in the workplace, with implications for occupational health, safety and social protection. We participate in several funded projects in the EU and North America (>17M euro in the past 6 years) and we publish widely on the effects of different environmental factors on human health and performance. Our group members provide input for guidelines and policy pertaining to the health effects of environmental factors for different international organizations (United Nations, World Health Organisation, European Commission, NASA, and others).